Health Today

The Outstanding Advantages of Low-Dose Naltrexone

On this interview, we assessment a number of the exceptional advantages of low-dose naltrexone (LDN), together with the shocking advantages of microdosed LDN. The 2 specialists featured on this interview are Linda Elsegood, a Briton who based the LDN Analysis Belief1 in 2004, and Dr. Sarah Zielsdorf, who has a medical observe within the Chicago space within the U.S.

Elsegood, who was recognized with MS in 2000, has been concerned in LDN analysis and public schooling for 16 years. LDN is a strong, protected and efficient therapy for a lot of autoimmune ailments, but few, together with most well being care professionals, know something about it. Remarkably, LDN might even be useful within the battle towards COVID-19, because it acts to normalize your immune system.2

Elsegood not too long ago revealed a e-book on LDN referred to as “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More.” Every chapter is written by a medical skilled with scientific data of the drug’s use. Zielsdorf is one of many contributing authors. Elsegood additionally hosts a radio present referred to as The LDN Radio Present.3

Within the interview, she tells the story of how she found LDN and the dramatic advantages she has skilled from it. In abstract, helpful results turned obvious after about three weeks on the drug and, after 18 months, her situation had considerably improved.

Zielsdorf — who has an undergraduate diploma in microbiology and a grasp’s diploma in public well being microbiology and rising infectious illness — additionally has a private well being story that introduced her to LDN. She was recognized with hypothyroidism (underactive thyroid) in 2003. Ten years later, she was recognized with Hashimoto’s, an autoimmune dysfunction that impacts the thyroid.

“I realized about practical vitamin and triggers for autoimmunity, and began to do all the issues I wanted to do to optimize my biomarkers, take away systemic irritation, and was in a position to return to my [medical] coaching. I had been instructed that I might by no means have kids and surprisingly turned pregnant and had a daughter in my second yr of coaching.

After having her, I [had a flareup]. It was then, in 2014, that a physician put me on LDN. It modified my life … As soon as I graduated from residency, I began treating sufferers with quite a lot of points with LDN. I’ve handled 1000’s of sufferers with LDN.”

Naltrexone — A Uncommon Gem of a Drug

Naltrexone in low and even microdoses is likely one of the few pharmaceutical medication I wholeheartedly endorse. Not solely is it remarkably protected, it’s additionally a profound adjunctive remedy for a large number of circumstances. As defined by Zielsdorf:

“Naltrexone is likely one of the few issues that really allows our personal our bodies, our personal immune methods, to have the ability to perform higher and actually restore perform.

After World Conflict II, they had been searching for extra opioid drugs. Accidentally, scientists discovered tips on how to block the opioid receptor. They did the precise reverse of what they had been alleged to do, which is to search out morphine analogs for troopers.

[In] the Nineteen Sixties, they had been in a position to synthesize naloxone and naltrexone … FDA authorised it within the Eighties for opioid habit at a dose of fifty to 100 milligrams, after which within the Nineties for alcohol dependence.

Nevertheless it was Dr. Bernard Bihari and Dr. Ian Zagon within the Seventies that had this wonderful concept that when you took a really small dose of naltrexone, compounding it in a clear approach [down] to some milligrams, if would briefly block the opioid receptor within the central nervous system — very briefly kissing that receptor after which unblocking it.

This upregulates the physique’s immune system by growing the opioid receptor’s personal manufacturing of beta-endorphin and met-enkephalins. Beta-endorphins assist with temper, ache, sleep and the immune system, and met-enkephalins are often known as opioid-derived development issue, and there are receptors for these on many various tissues, together with the thyroid.

We now use it for practically all autoimmune circumstances, as an adjunct for most cancers, and as a therapy for continual ache. We additionally use ultra-low dose [microdosed] naltrexone, which I wrote about, to assist potentiate ache aid for people who find themselves on opioids and assist them to be much less depending on opioid drugs.

I’ve really been in a position to get sufferers off of fentanyl patches and get them off continual oxycodone or Norco use the place their ache specialists mentioned, ‘You’ll by no means ever get off these ache drugs.’ It has been an unimaginable journey and I am an enormous advocate of it.”

Naloxone Versus Naltrexone

Naloxone (Narcan) is what’s carried on ambulances and utilized in ERs and trauma bays as an antidote to an opioid overdose. When given at a excessive sufficient dose, naloxone or Narcan acts as an entire opioid blocker, which is why it is used acutely when somebody has taken too excessive a dose of an opioid.

Naltrexone blocks the opioid receptor solely briefly, and by a special mechanism. When utilized in low dosages as LDN, the chief profit is definitely within the rebound impact, after the opioid receptor has been briefly blocked.

Foundational Therapy Methods for Autoimmune Illnesses

With regard to autoimmune diseases, it is essential to appreciate there are different, equally essential, foundational methods that can profit most sufferers with a dysfunctional immune system. These embody optimizing your vitamin D level and omega-3 index, for instance.

It is also essential to get rid of potential triggers. The rationale why folks have an autoimmune illness is as a result of they’re uncovered to one thing within the atmosphere which serves as an antigen that their physique acknowledges as a overseas invader, and in consequence assaults it. In case you can keep away from these antigens, you possibly can typically suppress and incessantly get rid of signs with out something, since you’ve eliminated the stimulus.

One widespread autoimmune set off is lectins, discovered in lots of in any other case wholesome greens. Zielsdorf will usually place her autoimmune sufferers on a Mediterranean-style paleo food regimen or an oligoantigenic elimination food regimen to optimize detoxing, liver and kidney perform, and the microbiome.

Others could also be positioned on a nose-to-tail carnivore diet. As famous by Zielsdorf, it’s “a approach of offloading and simplifying what antigens the physique is seeing.” Different useful diets on this respect embody the autoimmune paleo food regimen and the low-histamine or low FODMAP diet.

“I’m a microbiologist and I do a ton of superior testing, after which we begin wanting deeper at triggers,” she says. “I used to place all people on LDN first, however now we all know that sure sufferers will aptitude as a result of their immune system is so suppressed as a result of co-infections.

We see it most with Lyme illness and with yeast overgrowth. If I think or I’ve checks confirming {that a} affected person has one in every of this stuff, or their immune system is tremendous suppressed … I will work on their microbiome earlier than I begin LDN …

I take a look at all people’s intestine, and what I see universally is you get this hyper intense intestinal permeability in these circumstances … What’s so fascinating is a leaky intestine equals a leaky mind, and we overwhelm our immune system. I do see this. Step one is getting them off the most typical triggers, and typically I will be testing for lectins too.

Universally, for all of my autoimmune sufferers, is that they cannot eat wheat. There are over 150 antigens in wheat that you could be delicate to … It is usually desiccated with Roundup, glyphosate, proper earlier than processing, so we get that further toxicity. I take a look at my sufferers for his or her environmental poisonous load, and I see a whole lot of sufferers with glyphosate toxicity.

The wheat that we used to eat 10,000 years in the past in the beginning of agriculture isn’t the wheat [we now eat]. It is not even the identical chromosome quantity as what our our bodies ate in small quantities as hunter gatherers.”

Why You Ought to Keep away from Monogastric Animal Meats

As talked about by Zielsdorf, a nose-to-tail carnivore food regimen could be a superb intervention in some circumstances, particularly for these whose immune perform is severely suppressed. Nevertheless, you ought to keep away from monogastric animals, that means animals which have just one abdomen.

Whereas cows have two, chickens and pigs have just one. The rationale for this suggestion is as a result of conventionally manufacturing facility farmed rooster and pork shall be very excessive within the omega-6 fats linoleic acid. It is because they’re usually fed corn, which is excessive in the sort of fats. And a excessive linolenic acid food regimen can metabolically devastate your well being. So, a food regimen excessive in rooster and bacon isn’t doing all of your physique any favors.

Animals with two stomachs are in a position to totally course of omega-6-rich grains and different meals, as they’re outfitted with intestine micro organism that may break it down right into a more healthy fats. Other than cows and steer, this consists of buffalo, beef and lamb.

What Can LDN Deal with?

Other than autoimmune ailments, LDN can be used within the therapy of the next circumstances. Keep in mind this isn’t an entire listing. A few of these circumstances have been featured in varied documentaries4 produced by the LDN Analysis Belief. You’ll find hyperlinks to these documentaries within the references.

Most cancers5 — Analysis by professor Angus George Dalgleish and his colleague Dr. Wei Lou confirmed LDN might convey most cancers cells into remission utilizing pulse dosing.6 LDN additionally works synergistically with cannabidiol (CBD), and works properly for most cancers, autoimmunity and ache circumstances

Opioid habit, dependence and restoration7 — Utilizing microdoses of 0.001 milligrams (1 microgram), long-term customers of opioids who’ve developed a tolerance to the drug are in a position to, over time, decrease their opioid dose and keep away from withdrawal signs because the LDN makes the opioid simpler.

For opioid dependence, the everyday beginning dose is 1 microgram twice a day, which is able to permit them to decrease their opioid dose by about 60%. When the opioid is taken for ache, the LDN have to be taken 4 to 6 hours aside from the opioid in an effort to not displace the opioid’s results

Lyme illness and its coinfections8


Small intestinal bacterial overgrowth (SIBO)

Stressed leg syndrome


Dermatological points


Common Dosing Pointers

Dosing will, after all, depend upon the situation being handled, however there are some normal pointers that may be useful. Downloadable guides could be discovered on the LDN Analysis Belief web site, and can be found in a number of languages. Remember that LDN is a drug, not one thing you should buy over-the-counter, and it’s worthwhile to work with a educated doctor who can prescribe it and monitor your well being.

“With a normal ache situation, we might use 1.5 to three or 4.5 mg. With Hashimoto’s, we begin decrease and slower as a result of sufferers with Hashimoto’s may very well have to cut back their thyroid hormone remedy in the event that they’re on it as a result of they get discount of that irritation and so they can produce extra of their very own thyroid hormone. So, we often begin at 0.5 mg.

For sufferers with temper circumstances … 0.5 to 1 mg. There was an essential paper that got here out exhibiting LDN is a crucial agent for despair, for sufferers who fail these meds or as an adjunct to antidepressants. PTSD sufferers might need to go increased. There are all kinds of methods and also you simply want to search out a physician who’s well-versed in that situation.”

Extra Data

The LDN Research Trust’s website is a wonderful useful resource for all issues LDN. It has quite a lot of assets to information sufferers, prescribing medical doctors and pharmacists alike. It additionally has a web page the place you possibly can find LDN-literate prescribers world wide.

In fact, to study extra, you should definitely decide up a duplicate of “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More,” and/or “The LDN Book: How a Little-Known Generic Drug ― Low Dose Naltrexone ― Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression and More,” which is the primary of the 2 volumes.

Each books are also available on the LDN Research Trust website, together with movies that includes all the medical doctors that contributed chapters to the books. You may also take a look at The LDN Radio Present.9 Final however not least, LDN Analysis Belief is a nonprofit that is determined by public donations, so if you need to contribute to the Belief’s LDN analysis and schooling efforts, please make a donation.

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