What Works Greatest to Ease Migraines?




By Amy Norton
HealthDay Reporter

WEDNESDAY, June 16, 2021 (HealthDay Information) — A brand new analysis evaluation presents excellent news for migraine victims: There are extra pain-relieving choices than ever.

In an evaluation of over 100 revealed research, researchers discovered that a number of drug lessons confirmed good proof they ease the pain of a migraine-in-progress.

A few of these drugs have solely grow to be accessible up to now few years, opening up new choices for migraine victims who do not get sufficient reduction from outdated standby medicine.

Specialists mentioned the widening area of migraine remedies, which additionally embody nerve-stimulating gadgets, is encouraging.

“It is nice information there at the moment are many efficient remedies accessible,” mentioned Dr. Rebecca Burch, a neurologist at Brigham and Girls’s Hospital in Boston.

For anybody affected person, she famous, discovering the fitting remedy could take some trial-and-error — so persistence is essential.

“Keep it up. Do not hand over hope,” Burch mentioned. “If the primary remedy would not work, that does not imply nothing will.”

Burch co-wrote an editorial that accompanied the analysis evaluation within the June 15 problem of the Journal of the American Medical Affiliation.


The evaluation — which checked out 115 scientific trials and 15 earlier proof critiques — presents a wanted replace, mentioned lead creator Dr. Juliana VanderPluym.

“Over the previous three years or so, numerous new migraine therapies have grow to be accessible,” mentioned VanderPluym, an assistant professor of neurology on the Mayo Clinic in Scottsdale, Ariz.

They embody the oral drugs lasmiditan (Reyvow), which acts on a receptor for the hormone serotonin; and two “gepants” known as ubrogepant (Ubrelvy) and rimegepant (Nurtec).

Gepants intervene with CGRP, a small protein launched by the trigeminal nerve that performs a key function in producing migraine distress.

The evaluation discovered, unsurprisingly, sturdy proof supporting long-used migraine remedies — specifically, nonsteroidal anti-inflammatory medicine like ibuprofen (Advil, Motrin) and aspirin, and a category of migraine-specific medicine known as triptans.

All of these drugs beat placebos in lowering ache two hours right into a migraine assault, and someday later.

In the meantime, each lasmiditan and the gepants appeared good when it got here to lowering or erasing ache two hours into an assault, and someday later. (The energy of the proof was graded as “reasonable” to “excessive.”)


However for probably the most half, triptans stay the primary alternative for treating acute migraines, Burch mentioned.

Triptans work by focusing on serotonin (otherwise than lasmiditan). They’re typically efficient at dulling ache, however a draw back is that they constrict blood vessels. Which means individuals at elevated threat of coronary heart assault or stroke usually can not use them.

For another sufferers, Burch mentioned, triptans merely don’t work, or the unwanted side effects — like numbness, dizziness and sleepiness — make them troublesome to take.

That is the place alternate options are available in — although so, too, can the sensible problems with price and insurance coverage protection.

Each gepants and lasmiditan are costly, VanderPluym identified.

So insurance coverage, she mentioned, typically require sufferers to strive two triptans, or generally extra, earlier than they’ll cowl the pricier medicine.

Drugs aren’t the one remedy choice, although.

The evaluation discovered that a number of nerve-stimulating gadgets outperformed “sham” gadgets in easing migraine ache. The devices are used at house and make use of electrical or magnetic pulses to stimulate sure nerves concerned in ache signaling.


“Gadgets are an awesome choice for sufferers who need to keep away from drugs, or as an add-on to remedy,” VanderPluym mentioned.

However each she and Burch pointed to at least one barrier: price. Insurance coverage usually doesn’t cowl the gadgets, so sufferers can face excessive out-of-pocket bills.

The evaluation additionally highlights a medicine class that shouldn’t be used for migraine ache — opioids.

The medicine, equivalent to OxyContin and Vicodin, carry the dangers of harmful unwanted side effects and dependancy. And relating to migraine ache, they merely don’t work, Burch mentioned.

The underside line, in response to VanderPluym, is that the “proper” migraine remedy plan varies from individual to individual — and effectiveness, security and value all matter.

For individuals with longstanding migraines, she famous, this might be a superb time to revisit their remedy plan with their physician. Some may discover the newer choices are price a strive, VanderPluym mentioned.

The research was funded by the U.S. Company for Healthcare Analysis and High quality. VanderPluym has consulted for or obtained analysis funds from drugmakers Teva and Amgen.


Extra info

The U.S. Nationwide Institute of Neurological Issues and Stroke has extra on migraines.

SOURCES: Juliana VanderPluym, MD, assistant professor, neurology, Mayo Clinic, Scottsdale, Ariz.; Rebecca Burch, MD, neurologist, Brigham and Girls’s Hospital, and assistant professor, neurology, Harvard Medical College, Boston; Journal of the American Medical Affiliation, June 15, 2021